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Articles about Drug Discovery and Drug Delivery Systems

Indolequinone-based hypoxia-activated PROTACs (HAP-TACs) selectively degrade BRD4 in hypoxic cancer cells

2 days ago by Marta Serafini and others at

University of Oxford

Biological and Medicinal Chemistry, Chemical Biology

Overcoming cisplatin resistance via deep learning-assisted de novo design of platinum complexes

3 days ago by Daniil Rusanov and others

Biological and Medicinal Chemistry, Drug Discovery and Drug Delivery Systems

Discovery of YTHDF2 ligands by fragment-based design

4 days ago by Annalisa Invernizzi and others at

University of Zurich

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Structural Reassignment of Compound 968, an Allosteric Glutaminase Inhibitor

4 days ago by Lindsey Albertelli and others at

Biological and Medicinal Chemistry, Drug Discovery and Drug Delivery Systems

Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS(on) Alleles

6 days ago by Vesna Vetma and others at

University of Dundee

Biological and Medicinal Chemistry, Biophysics

Investigating the role of cytochrome bd oxidases in the antibacterial activity of madecassic acid and derivatives thereof

7 days ago by Samantha Henry and others at

University of Kent

Biological and Medicinal Chemistry, Chemical Biology

Understanding the role of H-bonds in the stability of molecular glue-induced ternary complexes

7 days ago by Patricia Blanco-Gabella and others

Theoretical and Computational Chemistry, Physical Chemistry

De novo macrocyclic glycopeptides by mRNA display to target macrophage galactose type lectin on dendritic cells

7 days ago by Ryoji Yoshisada and others at

Vrije Universiteit Amsterdam

Biological and Medicinal Chemistry, Biochemistry

An Integrin-Targeting Peptide Enables Efficient Lysosomal Delivery of Antibody-Drug Conjugates

13 June 2025 by Peter Szijj and others at

Stanford University

Biological and Medicinal Chemistry, Bioengineering and Biotechnology

Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties

13 June 2025 by Honoka Obata and others at

Duke University Medical Center

Biological and Medicinal Chemistry, Drug Discovery and Drug Delivery Systems

Molecular Paleontology Meets Drug Discovery: The Case for De-Extinct Antimicrobials

11 June 2025 by Rumiana Tenchov and Qiongqiong Angela Zhou at

Biological and Medicinal Chemistry, Drug Discovery and Drug Delivery Systems

Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines

11 June 2025 by Tatalina Oliveira and others

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Multiscale End-point Screening with Extended Tight-binding Hamiltonians

11 June 2025 by Xiaohui Wang and others

Theoretical and Computational Chemistry, Physical Chemistry

Flavonoid-Pectin Conjugates: Towards Broad Scope Therapeutic Agents

10 June 2025 by Caterina Sano and others

Biological and Medicinal Chemistry, Biochemistry

Enantioselective Total Synthesis of 5-Phenylmorphans and Cis-Octahydroisoquinolines

10 June 2025 by Abdulrahman Mahgoub and others

Biological and Medicinal Chemistry, Organic Chemistry

GPR3 ligands discovered through combined virtual and conformational biosensor-based screening

9 June 2025 by Hannes Schihada and others

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Optimization of Generator Reward Functions Targeting Non-covalent KRAS Inhibitors

6 June 2025 by Casey Galvin and others

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

High-throughput Triazole-based Combinatorial Click Chemistry for the Synthesis and Identification of Functional Metal Complexes

6 June 2025 by David Husbands and others at

University of York

Biological and Medicinal Chemistry, Inorganic Chemistry

Impact of Stereochemical Replacement on Activity and Selectivity of Membrane-Active Antibacterial and Antifungal Cyclic Peptides

6 June 2025 by Sandeep Lohan and others

Biological and Medicinal Chemistry, Bioinformatics and Computational Biology

De novo macrocyclic glycopeptides by mRNA display to target macrophage galactose type lectin on dendritic cells

4 June 2025 by Ryoji Yoshisada and others at

Vrije Universiteit Amsterdam

Biological and Medicinal Chemistry, Biochemistry

Development of Workflows for Discrete Standard Deposition Using Echo Acoustic Liquid Handlers for qMSI

4 June 2025 by Emily Sekera and others at

St. Jude Children's Research Hospital

Biological and Medicinal Chemistry, Analytical Chemistry

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

2 June 2025 by Paolo Rossetti and others

Biological and Medicinal Chemistry, Bioengineering and Biotechnology

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches of DNA Repair Enzyme OGG1

2 June 2025 by Marek Varga and others at

Karolinska Institutet

Biological and Medicinal Chemistry, Biochemistry

ADMETrix: ADMET-Driven De Novo Molecular Generation

2 June 2025 by Nikolaos Mourdoukoutas and others

Biological and Medicinal Chemistry, Drug Discovery and Drug Delivery Systems

All-atom Picture of Cucurbituril Detoxification Coordination

29 May 2025 by Xiaohui Wang and others at

Shenzhen University

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Optimization of Generator Reward Functions Targeting Non-covalent KRAS Inhibitors

29 May 2025 by Casey Galvin and others

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Self-Assembling Aromatic Peptide Amphiphile Fibers for Multivalent Display of Enzymatically Linked Antigenic Proteins

28 May 2025 by Rie Wakabayashi and others at

Kyushu University

Biological and Medicinal Chemistry, Drug Discovery and Drug Delivery Systems

Structure-Activity-Relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures

28 May 2025 by Harold Grosjean and others

Biological and Medicinal Chemistry, Biophysics

Development of a Non-Invasive Chitosan-Based Insulin Cream (W/O/W Emulsion) for Preventing Diabetic Kidney Disease

26 May 2025 by Hurriyet Polat and others

Biological and Medicinal Chemistry, Materials Science

Modular Synthetic Platform for Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery

23 May 2025 by Andres Gomez-Angel and others at

University of York

Biological and Medicinal Chemistry, Organic Chemistry

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