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Drug Discovery and Drug Delivery Systems
Indolequinone-based hypoxia-activated PROTACs (HAP-TACs) selectively degrade BRD4 in hypoxic cancer cells
2 days ago by
Marta Serafini
and
others
at
University of Oxford
Biological and Medicinal Chemistry
,
Chemical Biology
Overcoming cisplatin resistance via deep learning-assisted de novo design of platinum complexes
3 days ago by
Daniil Rusanov
and
others
Biological and Medicinal Chemistry
,
Drug Discovery and Drug Delivery Systems
Discovery of YTHDF2 ligands by fragment-based design
4 days ago by
Annalisa Invernizzi
and
others
at
University of Zurich
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Structural Reassignment of Compound 968, an Allosteric Glutaminase Inhibitor
4 days ago by
Lindsey Albertelli
and
others
at
Ithaca College
Biological and Medicinal Chemistry
,
Drug Discovery and Drug Delivery Systems
Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS(on) Alleles
6 days ago by
Vesna Vetma
and
others
at
University of Dundee
Biological and Medicinal Chemistry
,
Biophysics
Investigating the role of cytochrome bd oxidases in the antibacterial activity of madecassic acid and derivatives thereof
7 days ago by
Samantha Henry
and
others
at
University of Kent
Biological and Medicinal Chemistry
,
Chemical Biology
Understanding the role of H-bonds in the stability of molecular glue-induced ternary complexes
7 days ago by
Patricia Blanco-Gabella
and
others
Theoretical and Computational Chemistry
,
Physical Chemistry
De novo macrocyclic glycopeptides by mRNA display to target macrophage galactose type lectin on dendritic cells
7 days ago by
Ryoji Yoshisada
and
others
at
Vrije Universiteit Amsterdam
Biological and Medicinal Chemistry
,
Biochemistry
An Integrin-Targeting Peptide Enables Efficient Lysosomal Delivery of Antibody-Drug Conjugates
13 June 2025 by
Peter Szijj
and
others
at
Stanford University
Biological and Medicinal Chemistry
,
Bioengineering and Biotechnology
Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties
13 June 2025 by
Honoka Obata
and
others
at
Duke University Medical Center
Biological and Medicinal Chemistry
,
Drug Discovery and Drug Delivery Systems
Molecular Paleontology Meets Drug Discovery: The Case for De-Extinct Antimicrobials
11 June 2025 by
Rumiana Tenchov
and
Qiongqiong Angela Zhou
at
Cas
Biological and Medicinal Chemistry
,
Drug Discovery and Drug Delivery Systems
Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines
11 June 2025 by
Tatalina Oliveira
and
others
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Multiscale End-point Screening with Extended Tight-binding Hamiltonians
11 June 2025 by
Xiaohui Wang
and
others
Theoretical and Computational Chemistry
,
Physical Chemistry
Flavonoid-Pectin Conjugates: Towards Broad Scope Therapeutic Agents
10 June 2025 by
Caterina Sano
and
others
Biological and Medicinal Chemistry
,
Biochemistry
Enantioselective Total Synthesis of 5-Phenylmorphans and Cis-Octahydroisoquinolines
10 June 2025 by
Abdulrahman Mahgoub
and
others
Biological and Medicinal Chemistry
,
Organic Chemistry
GPR3 ligands discovered through combined virtual and conformational biosensor-based screening
9 June 2025 by
Hannes Schihada
and
others
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Optimization of Generator Reward Functions Targeting Non-covalent KRAS Inhibitors
6 June 2025 by
Casey Galvin
and
others
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
High-throughput Triazole-based Combinatorial Click Chemistry for the Synthesis and Identification of Functional Metal Complexes
6 June 2025 by
David Husbands
and
others
at
University of York
Biological and Medicinal Chemistry
,
Inorganic Chemistry
Impact of Stereochemical Replacement on Activity and Selectivity of Membrane-Active Antibacterial and Antifungal Cyclic Peptides
6 June 2025 by
Sandeep Lohan
and
others
Biological and Medicinal Chemistry
,
Bioinformatics and Computational Biology
De novo macrocyclic glycopeptides by mRNA display to target macrophage galactose type lectin on dendritic cells
4 June 2025 by
Ryoji Yoshisada
and
others
at
Vrije Universiteit Amsterdam
Biological and Medicinal Chemistry
,
Biochemistry
Development of Workflows for Discrete Standard Deposition Using Echo Acoustic Liquid Handlers for qMSI
4 June 2025 by
Emily Sekera
and
others
at
St. Jude Children's Research Hospital
Biological and Medicinal Chemistry
,
Analytical Chemistry
From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity
2 June 2025 by
Paolo Rossetti
and
others
Biological and Medicinal Chemistry
,
Bioengineering and Biotechnology
Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches of DNA Repair Enzyme OGG1
2 June 2025 by
Marek Varga
and
others
at
Karolinska Institutet
Biological and Medicinal Chemistry
,
Biochemistry
ADMETrix: ADMET-Driven De Novo Molecular Generation
2 June 2025 by
Nikolaos Mourdoukoutas
and
others
Biological and Medicinal Chemistry
,
Drug Discovery and Drug Delivery Systems
All-atom Picture of Cucurbituril Detoxification Coordination
29 May 2025 by
Xiaohui Wang
and
others
at
Shenzhen University
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Optimization of Generator Reward Functions Targeting Non-covalent KRAS Inhibitors
29 May 2025 by
Casey Galvin
and
others
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Self-Assembling Aromatic Peptide Amphiphile Fibers for Multivalent Display of Enzymatically Linked Antigenic Proteins
28 May 2025 by
Rie Wakabayashi
and
others
at
Kyushu University
Biological and Medicinal Chemistry
,
Drug Discovery and Drug Delivery Systems
Structure-Activity-Relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures
28 May 2025 by
Harold Grosjean
and
others
Biological and Medicinal Chemistry
,
Biophysics
Development of a Non-Invasive Chitosan-Based Insulin Cream (W/O/W Emulsion) for Preventing Diabetic Kidney Disease
26 May 2025 by
Hurriyet Polat
and
others
Biological and Medicinal Chemistry
,
Materials Science
Modular Synthetic Platform for Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery
23 May 2025 by
Andres Gomez-Angel
and
others
at
University of York
Biological and Medicinal Chemistry
,
Organic Chemistry
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