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Articles with tag Chemical Biology

Traversing Chemical Space with Active Deep Learning

23 November 2023 by Derek Van Tilborg and Francesca Grisoni at

Princeton University

Biological and Medicinal Chemistry, Bioinformatics and Computational Biology

sCIP-ing towards streamlined chemoproteomics

17 November 2023 by Nikolas Burton and Keriann M Backus at

UC Los Angeles

Biological and Medicinal Chemistry, Analytical Chemistry

A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction in vitro and in vivo independently of ROS induction

16 November 2023 by Keli Kuang and others at Sichuan University

Biological and Medicinal Chemistry, Biochemistry

Characterization of an N-Allylglyoxylamide Based Bioorthogonal Nitrone Trap

16 November 2023 by Daniel Lee and others at

University of Toronto

Biological and Medicinal Chemistry, Chemical Biology

Peptidomimetic inhibitors of β-strand mediated protein-protein interactions: tuning binding affinity of intrinsically disordered sequences by covalent backbone modification

16 November 2023 by Emma Cawood and others at

University of Birmingham

Biological and Medicinal Chemistry, Organic Chemistry

Kinetic Resolution of Epimeric Proteins enables Stereoselective Chemical Mutagenesis

15 November 2023 by Guljannat Ablat and others at

King's College London

Biological and Medicinal Chemistry, Biochemistry

Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the Ataxia telangiectasia and RAD3-related (ATR) kinase

10 November 2023 by Abdallah Alfayomy and others at

Mainz Institute for Theoretical Physics

Biological and Medicinal Chemistry, Cell and Molecular Biology

Traversing Chemical Space with Active Deep Learning

8 November 2023 by Derek Van Tilborg and Francesca Grisoni at

Princeton University

Biological and Medicinal Chemistry, Bioinformatics and Computational Biology

Novel far-red fluorescent 1,4-dihydropyridines for L-type calcium channels imaging

7 November 2023 by Carlotta Borgarelli and others at

KU Leuven

Biological and Medicinal Chemistry, Organic Chemistry

Reshaping Echinocandin Antifungal Drugs to Circumvent Glucan Synthase Point Mutation-Mediated Resistance

3 November 2023 by Moriah Jospe-kaufman and others at

Tel Aviv University

Biological and Medicinal Chemistry, Chemical Biology

DNA Mimic Foldamer Recognition of a Chromosomal Protein

3 November 2023 by Deepak Deepak and others

Biological and Medicinal Chemistry, Organic Chemistry

Copper's dual influence: Self-assembly and anti-amyloidogenic activity of monomeric transthyretin

31 October 2023 by Yelim Yi and others at Korea Advanced Institute of Science and Technology

Biological and Medicinal Chemistry, Inorganic Chemistry

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B

31 October 2023 by Davia Prischich and others

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Poacic Acid, a Plant-Derived Stilbenoid, Augments Cell-Wall Chitin Production, but Its Antifungal Activity Is Hindered by this Polysaccharide and by Fungal Essential Metals

27 October 2023 by Adi Yona and Micha Fridman at

Tel Aviv University

Biological and Medicinal Chemistry, Chemical Biology

C-4 analogs of podophyllotoxin as tubulin inhibitors: Synthesis, biological evaluation, and structure-activity relationship

27 October 2023 by Breanna Lu and others

Biological and Medicinal Chemistry, Organic Chemistry

Azole reagents enabled ligation of peptide acyl pyrazoles for chemical protein synthesis

27 October 2023 by Peisi Liao and Chunmao He at

South China University of Technology

Biological and Medicinal Chemistry, Chemical Biology

Antifungal and Antiparasitic Activity of Novel Metallocene-containing Fluconazole Derivatives

27 October 2023 by Yan Lin and others at

University of Zurich

Biological and Medicinal Chemistry, Inorganic Chemistry

Synthesis of C3-Substituted N1-tert-Butyl 1,2,4-Triazinium Salts via the Liebeskind–Srogl Reaction for Fluorogenic Labeling of Live Cells

27 October 2023 by Veronika Šlachtová and others

Biological and Medicinal Chemistry, Chemical Biology

Flipping the GPCR Switch: Structure–Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists

27 October 2023 by Erick Carreira and others at ETH Zurich

Biological and Medicinal Chemistry, Organic Chemistry

Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization

26 October 2023 by Frances Smith and others at University of Nottingham

Biological and Medicinal Chemistry, Organic Chemistry

Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization

25 October 2023 by Frances Smith and others at University of Nottingham

Biological and Medicinal Chemistry, Organic Chemistry

Photoresponsive adenosine derivatives for optical control of adenosine A2A receptor in living cells

25 October 2023 by Harufumi Suzuki and others

Biological and Medicinal Chemistry, Organic Chemistry

Crystal Structure Reveals the Binding Mode and Selectivity of a Photoswitchable Ligand for the Adenosine A2A Receptor

25 October 2023 by Tsuyoshi Araya and others at

Kyoto University

Biological and Medicinal Chemistry, Organic Chemistry

New insights from old data - Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter

20 October 2023 by Jason R Thomas and others

Theoretical and Computational Chemistry, Biological and Medicinal Chemistry

Soft drug-inhibitors for the epigenetic targets Lysine-Specific Demethylase 1 (LSD1) and Histone Deacetylases (HDACs)

20 October 2023 by Johannes Seitz and others at University of Freiburg

Biological and Medicinal Chemistry, Biochemistry

Development of stapled NONO-associated peptides reveals unexpected cell permeability and nuclear localisation

18 October 2023 by Reginald Young and others at

University of Sydney

Biological and Medicinal Chemistry, Chemical Biology

Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice

17 October 2023 by Xuan Liang and others at Peking University

Biological and Medicinal Chemistry, Catalysis

Distinct aggregation and toxicity of N-terminally truncated Abeta4-42 over Abeta1-42 in the presence of Zn(II)

17 October 2023 by Chanju Na and others at

Harvard Medical School

Biological and Medicinal Chemistry, Biochemistry

Fixing flavins: hijacking a flavin transferase for equipping flavoproteins with a covalent flavin cofactor

13 October 2023 by Yapei Tong and others at

University of Groningen

Biological and Medicinal Chemistry, Catalysis

Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease

13 October 2023 by Vasco Neto and others

Biological and Medicinal Chemistry, Biochemistry