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Chemical Biology
Traversing Chemical Space with Active Deep Learning
23 November 2023 by
Derek Van Tilborg
and
Francesca Grisoni
at
Princeton University
Biological and Medicinal Chemistry
,
Bioinformatics and Computational Biology
sCIP-ing towards streamlined chemoproteomics
17 November 2023 by
Nikolas Burton
and
Keriann M Backus
at
UC Los Angeles
Biological and Medicinal Chemistry
,
Analytical Chemistry
A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction in vitro and in vivo independently of ROS induction
16 November 2023 by
Keli Kuang
and
others
at
Sichuan University
Biological and Medicinal Chemistry
,
Biochemistry
Characterization of an N-Allylglyoxylamide Based Bioorthogonal Nitrone Trap
16 November 2023 by
Daniel Lee
and
others
at
University of Toronto
Biological and Medicinal Chemistry
,
Chemical Biology
Peptidomimetic inhibitors of β-strand mediated protein-protein interactions: tuning binding affinity of intrinsically disordered sequences by covalent backbone modification
16 November 2023 by
Emma Cawood
and
others
at
University of Birmingham
Biological and Medicinal Chemistry
,
Organic Chemistry
Kinetic Resolution of Epimeric Proteins enables Stereoselective Chemical Mutagenesis
15 November 2023 by
Guljannat Ablat
and
others
at
King's College London
Biological and Medicinal Chemistry
,
Biochemistry
Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the Ataxia telangiectasia and RAD3-related (ATR) kinase
10 November 2023 by
Abdallah Alfayomy
and
others
at
Mainz Institute for Theoretical Physics
Biological and Medicinal Chemistry
,
Cell and Molecular Biology
Traversing Chemical Space with Active Deep Learning
8 November 2023 by
Derek Van Tilborg
and
Francesca Grisoni
at
Princeton University
Biological and Medicinal Chemistry
,
Bioinformatics and Computational Biology
Novel far-red fluorescent 1,4-dihydropyridines for L-type calcium channels imaging
7 November 2023 by
Carlotta Borgarelli
and
others
at
KU Leuven
Biological and Medicinal Chemistry
,
Organic Chemistry
Reshaping Echinocandin Antifungal Drugs to Circumvent Glucan Synthase Point Mutation-Mediated Resistance
3 November 2023 by
Moriah Jospe-kaufman
and
others
at
Tel Aviv University
Biological and Medicinal Chemistry
,
Chemical Biology
DNA Mimic Foldamer Recognition of a Chromosomal Protein
3 November 2023 by
Deepak Deepak
and
others
Biological and Medicinal Chemistry
,
Organic Chemistry
Copper's dual influence: Self-assembly and anti-amyloidogenic activity of monomeric transthyretin
31 October 2023 by
Yelim Yi
and
others
at
Korea Advanced Institute of Science and Technology
Biological and Medicinal Chemistry
,
Inorganic Chemistry
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
31 October 2023 by
Davia Prischich
and
others
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Poacic Acid, a Plant-Derived Stilbenoid, Augments Cell-Wall Chitin Production, but Its Antifungal Activity Is Hindered by this Polysaccharide and by Fungal Essential Metals
27 October 2023 by
Adi Yona
and
Micha Fridman
at
Tel Aviv University
Biological and Medicinal Chemistry
,
Chemical Biology
C-4 analogs of podophyllotoxin as tubulin inhibitors: Synthesis, biological evaluation, and structure-activity relationship
27 October 2023 by
Breanna Lu
and
others
Biological and Medicinal Chemistry
,
Organic Chemistry
Azole reagents enabled ligation of peptide acyl pyrazoles for chemical protein synthesis
27 October 2023 by
Peisi Liao
and
Chunmao He
at
South China University of Technology
Biological and Medicinal Chemistry
,
Chemical Biology
Antifungal and Antiparasitic Activity of Novel Metallocene-containing Fluconazole Derivatives
27 October 2023 by
Yan Lin
and
others
at
University of Zurich
Biological and Medicinal Chemistry
,
Inorganic Chemistry
Synthesis of C3-Substituted N1-tert-Butyl 1,2,4-Triazinium Salts via the Liebeskind–Srogl Reaction for Fluorogenic Labeling of Live Cells
27 October 2023 by
Veronika Šlachtová
and
others
Biological and Medicinal Chemistry
,
Chemical Biology
Flipping the GPCR Switch: Structure–Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
27 October 2023 by
Erick Carreira
and
others
at
ETH Zurich
Biological and Medicinal Chemistry
,
Organic Chemistry
Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization
26 October 2023 by
Frances Smith
and
others
at
University of Nottingham
Biological and Medicinal Chemistry
,
Organic Chemistry
Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization
25 October 2023 by
Frances Smith
and
others
at
University of Nottingham
Biological and Medicinal Chemistry
,
Organic Chemistry
Photoresponsive adenosine derivatives for optical control of adenosine A2A receptor in living cells
25 October 2023 by
Harufumi Suzuki
and
others
Biological and Medicinal Chemistry
,
Organic Chemistry
Crystal Structure Reveals the Binding Mode and Selectivity of a Photoswitchable Ligand for the Adenosine A2A Receptor
25 October 2023 by
Tsuyoshi Araya
and
others
at
Kyoto University
Biological and Medicinal Chemistry
,
Organic Chemistry
New insights from old data - Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter
20 October 2023 by
Jason R Thomas
and
others
Theoretical and Computational Chemistry
,
Biological and Medicinal Chemistry
Soft drug-inhibitors for the epigenetic targets Lysine-Specific Demethylase 1 (LSD1) and Histone Deacetylases (HDACs)
20 October 2023 by
Johannes Seitz
and
others
at
University of Freiburg
Biological and Medicinal Chemistry
,
Biochemistry
Development of stapled NONO-associated peptides reveals unexpected cell permeability and nuclear localisation
18 October 2023 by
Reginald Young
and
others
at
University of Sydney
Biological and Medicinal Chemistry
,
Chemical Biology
Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice
17 October 2023 by
Xuan Liang
and
others
at
Peking University
Biological and Medicinal Chemistry
,
Catalysis
Distinct aggregation and toxicity of N-terminally truncated Abeta4-42 over Abeta1-42 in the presence of Zn(II)
17 October 2023 by
Chanju Na
and
others
at
Harvard Medical School
Biological and Medicinal Chemistry
,
Biochemistry
Fixing flavins: hijacking a flavin transferase for equipping flavoproteins with a covalent flavin cofactor
13 October 2023 by
Yapei Tong
and
others
at
University of Groningen
Biological and Medicinal Chemistry
,
Catalysis
Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease
13 October 2023 by
Vasco Neto
and
others
Biological and Medicinal Chemistry
,
Biochemistry
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