Articles by Jay Shendure | Synthical

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60

A molecular proximity sensor based on an engineered, dual-component guide RNA

12 February 2025 by Junyoung Choi and others

Synthetic Biology

Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types

15 January 2025 by Vipul Agarwal and others

An improved, high yield method for isolating nuclei from individual zebrafish embryos for single-nucleus RNA sequencing

22 November 2024 by Clifford Rostomily and others

How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities

14 October 2024 by Charlotte Bunne and others at

Quantitative Methods, Artificial Intelligence

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements

18 September 2024 by F. Chardon and others at

University of Washington

Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

26 August 2024 by D. Read and others at

University of Washington

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

23 May 2024 by H. Thirimanne and others

Chromatin context-dependent regulation and epigenetic manipulation of prime editing

11 April 2024 by Xueqing Li and others at

University of Washington

Molecular Biology

Local-Scale phylodynamics reveal differential community impact of SARS-CoV-2 in metropolitan US county

26 March 2024 by M. Paredes and others

Infectious Diseases

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

25 January 2024 by J. Mcfaline-Figueroa and others at

Columbia University

Transgene directed induction of a stem cell-derived human embryo model

27 June 2023 by B. A. T. Weatherbee and others at

University of Cambridge

Developmental Biology

Mapping the emergence of SARS-CoV-2 Omicron variants on a university campus

6 September 2022 by A. Weil and others

An optimized protocol for single cell transcriptional profiling by combinatorial indexing

2 November 2021 by Beth Martin and others

Precise genomic deletions using paired prime editing

14 October 2021 by Junyoung Choi and others

Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation

27 September 2021 by G. Bonora and others at

University of Washington

The landscape of alternative polyadenylation in single cells of the developing mouse embryo

24 August 2021 by Vipul Agarwal and others at

University of Washington

Preliminary support for a 'dry swab, extraction free' protocol for SARS-CoV-2 testing via RT-qPCR

1 July 2021 by Sanjay Srivatsan and others at

University of Washington

Molecular Biology

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

10 June 2021 by K. Simeonov and others at

University of Pennsylvania

Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State

3 May 2021 by N. Mueller and others at

Fred Hutchinson Cancer Research Center

Comprehensive characterization of tissue-specific chromatin accessibility in L2 Caenorhabditis elegans nematodes

22 April 2021 by T. Durham and others at

University of Washington

Genome-wide strand asymmetry in massively parallel reporter activity favors genic strands

20 April 2021 by B. Roberts and others

Comparable specimen collection from both ends of at-home mid-turbinate swabs

17 February 2021 by Mimi Truong and others

Infectious Diseases

Trans- and cis-acting effects of the lncRNA Firre on epigenetic and structural features of the inactive X chromosome

27 November 2020 by Hanpei Fang and others at

University of Washington

A systematic evaluation of the design, orientation, and sequence context dependencies of massively parallel reporter assays

12 October 2020 by J. Klein and others at

University of Washington

The Seattle Flu Study: a multi-arm community-based prospective study protocol for assessing influenza prevalence, transmission, and genomic epidemiology

8 October 2020 by H. Chu and others

Infectious Diseases

A Genomic Survey of SARS-CoV-2 Reveals Multiple Introductions into Northern California without a Predominant Lineage

8 June 2020 by Xiaojun Deng and others at

UC San Francisco

Infectious Diseases

Predicting mRNA abundance directly from genomic sequence using deep convolutional neural networks

19 May 2020 by Vipul Agarwal and Jay Shendure at

University of Washington

Suppressor mutations in Mecp2-null mice reveal that the DNA damage response is key to Rett syndrome pathology

21 April 2020 by A. Enikanolaiye and others

Characterizing the temporal dynamics of gene expression in single cells with sci-fate

13 April 2020 by Jinghan Cao and others at

University of Washington

Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures

20 December 2019 by Varun Rai and others at

University of Michigan

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Genomics Infectious Diseases Genetics Developmental Biology Cancer Biology Molecular Biology Epidemiology Bioinformatics Bioengineering Other Quantitative Biology Evolutionary Biology Biological Physics