scSemiProfiler: Advancing Large-scale Single-cell Studiesthrough Semi-profiling with Deep Generative Models andActive Learning

AbstractSingle-cell sequencing is a crucial tool for dissecting the cellular intricacies of complex diseases. Its prohibitive cost, however, hampers its application in expansive biomedical studies. Traditional cellular deconvolution approaches can infer cell type proportions from more affordable bulk sequencing data, yet they fall short in providing the detailed resolution required... Show more