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How sequence alignment scores correspond to probability models

By Martin Frith
Sequence alignment remains fundamental in bioinformatics. Pairwise alignment is traditionally based on ad hoc scores for substitutions, insertions, and deletions, but can also be based on probability models (pair hidden Markov models: PHMMs). PHMMs enable us to: fit the parameters to each kind of data, calculate the reliability of alignment... Show more
July 19, 2019
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How sequence alignment scores correspond to probability models
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