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XIST ribonucleoproteins promote female sex-biased autoimmunity

By D. Dou and others at
LogoStanford University
Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long noncoding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist... Show more
February 1, 2024
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