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AMP-activated protein kinase and adenylate kinase prevent ATP catastrophe and cytotoxic protein aggregation

By M. Takaine and others at
LogoGunma University
ATP at millimolar levels has recently been implicated in the solubilization of cellular proteins. However, the significance of this high ATP level under physiological conditions and the mechanisms that maintain ATP remain unclear. We herein demonstrated that AMP-activated protein kinase (AMPK) and adenylate kinase (ADK) cooperated to maintain cellular ATP... Show more
April 19, 2022
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AMP-activated protein kinase and adenylate kinase prevent ATP catastrophe and cytotoxic protein aggregation
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