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Targeting endometrial cancer stem cell activity with metformin is inhibited by patient-derived adipocyte-secreted factors

By S. Kitson and others at
LogoUniversity of Manchester
Translational relevanceEndometrial cancer stem cells are reported to drive metastasis and disease relapse and are resistant to commonly used chemotherapeutic drugs. Here, we characterise ALDHhigh and CD133+ve endometrial cancer stem cells with differing levels of cancer stem cell activity and stem cell and epithelial-mesenchymal transition (EMT) gene expression. Their proportions... Show more
May 13, 2019
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Targeting endometrial cancer stem cell activity with metformin is inhibited by patient-derived adipocyte-secreted factors
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