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Modular, Atroposelective Total Synthesis of Micitide 982

By Hiroshige Ogawa and others at
LogoHong Kong University of Science and Technology
A modular, atroposelective total synthesis of micitide 982 (1) is reported. The feature of this report is the gram-scale C-H biarylation of N-phthaloyl-L-alanine followed by atroposelective Larock macrocyclization. This modular approach allowed the construction of a highly strained atrop-Tyr-Trp cross-linkage with unprecedented atropisomerism, as well as the first total synthesis... Show more
May 15, 2024
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