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Evidence that nuclear receptors evolved from terpene synthases

By D. Houston and others
Ligand-activated nuclear receptors (NRs) including steroid receptors orchestrate development, growth, and reproduction across all animal lifeforms - the Metazoa - but how NRs evolved remains mysterious. Given the universality of terpenoids - including steroids and retinoids - as activating NR ligands, we asked if NRs might have evolved from enzymes... Show more
February 3, 2022
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Evidence that nuclear receptors evolved from terpene synthases
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