15:{"metadata":[["$","title","0",{"children":"In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model"}],["$","meta","1",{"name":"description","content":"In the aim to design small molecules capable of binding in vivo to albumin to form\nbioconjugates, a second generation GluCAB derivative(Glucose-Chelator-Albumin\nBioconjugate) has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models\ntogether with its first-generation analogue. This series of radioligands - also\ncapable of complexing therapeutic isotopes and therefore classified as\ntheranostic agents - are working on the principle of tumor targeting through\nthe Enhanced Permeability and Retention (EPR) effect as well as glucose\nmetabolism."}],["$","meta","2",{"name":"author","content":"Thomas Le Bihan"}],["$","meta","3",{"name":"author","content":"Cathryn H.S. Driver"}],["$","meta","4",{"name":"author","content":"Thomas Ebenhan"}],["$","meta","5",{"name":"author","content":"Nathalie Le Bris"}],["$","meta","6",{"name":"author","content":"Jan Rijn Zeevaart"}],["$","meta","7",{"name":"author","content":"Raphael Tripier"}],["$","meta","8",{"name":"keywords","content":"Bioinorganic Chemistry,Nuclear Chemistry,Biochemistry,Coordination Chemistry"}],["$","meta","9",{"name":"referrer","content":"origin"}],["$","meta","10",{"name":"robots","content":"index, follow"}],["$","link","11",{"rel":"canonical","href":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee"}],["$","link","12",{"rel":"alternate","hrefLang":"de-DE","href":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee/de"}],["$","link","13",{"rel":"alternate","hrefLang":"fr-FR","href":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee/fr"}],["$","link","14",{"rel":"alternate","hrefLang":"es-ES","href":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee/es"}],["$","link","15",{"rel":"alternate","hrefLang":"it-IT","href":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee/it"}],["$","link","16",{"rel":"alternate","hrefLang":"ru-RU","href":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee/ru"}],["$","meta","17",{"property":"og:title","content":"In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model"}],["$","meta","18",{"property":"og:description","content":"In the aim to design small molecules capable of binding in vivo to albumin to form\nbioconjugates, a second generation GluCAB derivative(Glucose-Chelator-Albumin\nBioconjugate) has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models\ntogether with its first-generation analogue. This series of radioligands - also\ncapable of complexing therapeutic isotopes and therefore classified as\ntheranostic agents - are working on the principle of tumor targeting through\nthe Enhanced Permeability and Retention (EPR) effect as well as glucose\nmetabolism."}],["$","meta","19",{"property":"og:url","content":"https://synthical.com/article/In-Vivo-Albumin-Binding-of-a-C-Functionalized-Cyclam-Platform-for-64Cu-PET%2FCT-Imaging-in-Breast-Cancer-Model-abbf06d2-1a43-11ee-81a9-72fd4f0b0eee"}],["$","meta","20",{"property":"og:site_name","content":"Synthical"}],["$","meta","21",{"property":"og:locale","content":"en-US"}],["$","meta","22",{"property":"og:image","content":"https://synthical.com/preview/article/abbf06d2-1a43-11ee-81a9-72fd4f0b0eee"}],["$","meta","23",{"property":"og:image:alt","content":"In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model"}],["$","meta","24",{"property":"og:image:width","content":"1200"}],["$","meta","25",{"property":"og:image:height","content":"630"}],["$","meta","26",{"property":"og:type","content":"article"}],["$","meta","27",{"property":"article:published_time","content":"2020-07-27T10:40:06.000Z"}],["$","meta","28",{"property":"article:modified_time","content":"2020-07-27T10:40:06.000Z"}],["$","meta","29",{"property":"article:author:name","content":"Thomas Le Bihan"}],["$","meta","30",{"property":"article:author:id","content":"d943cc74-623a-47f2-94a2-96ab1e2c8245"}],["$","meta","31",{"property":"article:author:alternatives","content":"Thomas Le Bihan,T. L. Bihan"}],["$","meta","32",{"property":"article:author:avatar","content":"default_1"}],["$","meta","33",{"property":"article:author:articles_count","content":"2"}],["$","meta","34",{"property":"article:author:name","content":"Cathryn H.S. Driver"}],["$","meta","35",{"property":"article:author:id","content":"6c5e71e9-7813-49cd-82b0-2966633239db"}],["$","meta","36",{"property":"article:author:alternatives","content":"Cathryn H.s. Driver"}],["$","meta","37",{"property":"article:author:avatar","content":"default_8"}],["$","meta","38",{"property":"article:author:articles_count","content":"2"}],["$","meta","39",{"property":"article:author:name","content":"Thomas Ebenhan"}],["$","meta","40",{"property":"article:author:id","content":"ae9fc6bf-ac64-4053-b48c-86401ac790dd"}],["$","meta","41",{"property":"article:author:alternatives","content":"Thomas Ebenhan,T. Ebenhan"}],["$","meta","42",{"property":"article:author:avatar","content":"default_5"}],["$","meta","43",{"property":"article:author:articles_count","content":"2"}],["$","meta","44",{"property":"article:author:name","content":"Nathalie Le Bris"}],["$","meta","45",{"property":"article:author:id","content":"efcfcf41-726c-4ef4-90ed-85b66d3cfe19"}],["$","meta","46",{"property":"article:author:alternatives","content":"Nathalie Le Bris,N. L. Bris"}],["$","meta","47",{"property":"article:author:avatar","content":"default_8"}],["$","meta","48",{"property":"article:author:articles_count","content":"3"}],["$","meta","49",{"property":"article:author:name","content":"Jan Rijn Zeevaart"}],["$","meta","50",{"property":"article:author:id","content":"d6b5544b-4abf-4721-abcf-ac9eb8d04350"}],["$","meta","51",{"property":"article:author:alternatives","content":"Jan Rijn Zeevaart,J. R. Zeevaart"}],["$","meta","52",{"property":"article:author:avatar","content":"default_8"}],["$","meta","53",{"property":"article:author:articles_count","content":"2"}],["$","meta","54",{"property":"article:author:name","content":"Raphael Tripier"}],["$","meta","55",{"property":"article:author:id","content":"57c76f37-482e-480d-afbb-0f3a4c7c02c9"}],["$","meta","56",{"property":"article:author:alternatives","content":"Raphael Tripier,R. Tripier"}],["$","meta","57",{"property":"article:author:avatar","content":"default_8"}],["$","meta","58",{"property":"article:author:articles_count","content":"12"}],["$","meta","59",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","60",{"name":"twitter:title","content":"In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model"}],["$","meta","61",{"name":"twitter:description","content":"In the aim to design small molecules capable of binding in vivo to albumin to form\nbioconjugates, a second generation GluCAB derivative(Glucose-Chelator-Albumin\nBioconjugate) has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models\ntogether with its first-generation analogue. This series of radioligands - also\ncapable of complexing therapeutic isotopes and therefore classified as\ntheranostic agents - are working on the principle of tumor targeting through\nthe Enhanced Permeability and Retention (EPR) effect as well as glucose\nmetabolism."}],["$","meta","62",{"name":"twitter:image","content":"https://synthical.com/preview/article/abbf06d2-1a43-11ee-81a9-72fd4f0b0eee"}],["$","meta","63",{"name":"twitter:image:alt","content":"In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model"}],["$","meta","64",{"name":"twitter:image:width","content":"1200"}],["$","meta","65",{"name":"twitter:image:height","content":"630"}],["$","link","66",{"rel":"icon","href":"/favicon-32x32.png"}],["$","link","67",{"rel":"apple-touch-icon","href":"/apple-touch-icon.png"}]],"error":null,"digest":"$undefined"}