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Wild Type α-Synuclein Structure and Aggregation: A Comprehensive Coarse-Grained and All-Atom Molecular Dynamics Study

By Gabriel Martins and Nuno Galamba
α-synuclein (α-syn) is a 140-amino acid intrinsically disordered protein (IDP) and the primary component of cytotoxic oligomers implicated in the etiology of Parkinson's disease (PD). While IDPs lack a stable three-dimensional structure they sample a heterogeneous ensemble of conformations that can, in principle, be assessed through molecular dynamics simulations. However,... Show more
June 11, 2024
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Wild Type α-Synuclein Structure and Aggregation: A Comprehensive Coarse-Grained and All-Atom Molecular Dynamics Study
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