Sign in

Trifluoroacetic Acid Mediated Additive-free Late-Stage Native Pep-tide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones

By Yisa Xiao and others at
LogoUniversity of Hong Kong
Peptide cyclization is often used to introduce conformational rigidity and enhance the physiological stability of the peptide. This study presents a novel late-stage cyclization method for creating thioketal cyclic peptides from bis-cysteine peptides and drugs. Symmetrical cyclic ketones and acetone were found to react with bis-cysteine unprotected peptides efficiently to... Show more
July 9, 2024
=
0
Loading PDF…
Loading full text...
Similar articles
Loading recommendations...
=
0
x1
Trifluoroacetic Acid Mediated Additive-free Late-Stage Native Pep-tide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones
Click on play to start listening