Solvent- and catalyst-free aza-Michael addition of imidazoles and related heterocycles

This work demonstrates the scope and limitations of the aza-Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent- and catalyst-free conditions. The reaction proceeds at 80°C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been... Show more