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Sickle Cell Hemoglobin Drugged with Cyclic Peptides is Aggregation Incompetent

By Nuno Galamba at
LogoUniversidade de Lisboa
Sickle cell disease is a monogenic blood disorder associated with a mutation in the HBB gene encoding for the β-globin of normal adult hemoglobin (HbA). This mutation transcribes into a Gluβ6→Val-β6 substitution in the β-globins, inducing the polymerization of this hemoglobin form (HbS) when in the T-state. Despite advances in... Show more
June 11, 2024
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Sickle Cell Hemoglobin Drugged with Cyclic Peptides is Aggregation Incompetent
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