Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons

The eukaryotic 43S pre-initiation complex (PIC) bearing Met-tRNA[Formula] in a ternary complex (TC) with eIF2-GTP scans the mRNA leader for an AUG codon in favorable \"Kozak\" context. AUG recognition provokes rearrangement from an open PIC conformation with TC bound in a state not fully engaged with the P site (\"POUT\")... Show more