Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on macrophages and is required for self-renewal but the mechanisms responsible are unknown. Using GM-CSF receptor-{beta}-chain deficient (Csf2rb-/-) mice, we show GM-CSF is critical for mitochondrial turnover, functions, and integrity. GM-CSF signaling is essential for fatty acid {beta}-oxidation and markedly increased tricarboxylic acid... Show more