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Re-engineering lysozyme solubility and activity through surfactant complexation

By Jiaming Mu and others at
LogoQueen's University Belfast
and
LogoThe Queen's University Belfast
Hydrophobic ion-pairing is an established solubility engineering technique that uses amphiphilic surfactants to modulate drug lipophilicity and facilitate encapsulation in polymeric and lipid-based drug delivery systems. For proteins, surfactant complexation can also lead to unfolding processes and loss in bioactivity. In this study, we investigated the impact of two surfactants,... Show more
July 10, 2024
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Re-engineering lysozyme solubility and activity through surfactant complexation
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