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RNA-FrameFlow: Flow Matching for de novo 3D RNA Backbone Design

By Rishabh Anand and others at
LogoNational University of Singapore
and
LogoUniversity of Cambridge
We introduce RNA-FrameFlow, the first generative model for 3D RNA backbone design. We build upon SE(3) flow matching for protein backbone generation and establish protocols for data preparation and evaluation to address unique challenges posed by RNA modeling. We formulate RNA structures as a set of rigid-body frames and associated... Show more
June 19, 2024
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RNA-FrameFlow: Flow Matching for de novo 3D RNA Backbone Design
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