Probing the Intramolecular Folding of Nucleic Acids with Native Ion Mobility Mass Spectrometry: Strategies and Caveats

The goal of native mass spectrometry is to obtain information on non-covalent interactions in solution through mass spectrometry measurements in the gas phase. Characterizing intramolecular folding re-quires using structural probing techniques such as ion mobility spectrometry. However, inferring solu-tion structures of nucleic acids is difficult because the low-charge state ions... Show more