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Phosphorylation barcodes direct biased chemokine signaling at CXCR3

By D. Eiger and others
G protein-coupled receptor (GPCR) biased agonism, the activation of some signaling pathways over others, is thought to largely be due to differential receptor phosphorylation, or "phosphorylation barcodes." At chemokine receptors, ligands act as "biased agonists" with complex signaling profiles, which contributes to the limited success in pharmacologically targeting these receptors.... Show more
April 7, 2023
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Phosphorylation barcodes direct biased chemokine signaling at CXCR3
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