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Phosphorylated Lamin A targets active enhancers and is associated with abnormal transcriptional activation in progeria

By Kosai Ikegami and others at
LogoUniversity of Chicago
LMNA encodes nuclear lamin A/C that tethers lamina-associated heterochromatin domains (LADs) to the nuclear periphery. Point mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown. We report that Ser22-phosphorylated Lamin A/C (pS22-Lamin A/C) was localized to the interior of the nucleus... Show more
March 23, 2020
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Phosphorylated Lamin A targets active enhancers and is associated with abnormal transcriptional activation in progeria
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