Parallel G-duplex and C-duplex DNA with Uninterrupted Spines of AgI-Mediated Base Pairs

Hydrogen bonding between nucleobases produces diverse DNA structural motifs, including canonical duplexes, guanine (G) quadruplexes and cytosine (C) i-motifs. Incorporating metal-mediated base pairs into nucleic acid structures can introduce new functionalities and enhanced stabilities. Here we demonstrate, using mass spectrometry (MS) and fluorescence resonance energy transfer (FRET), that parallel-stranded structures... Show more