On-Strand Aldehyde Capture by an Indanone Building Block: A Modular Aldol Approach for Fluorescent Molecular Rotor Nucleobase Surrogates

Fluorescent molecular rotors (FMRs) are critical tools for monitoring nucleic acid structure and function. Many valuable probes are capable of sitespecific insertion into oligonucleotides, although the methods of doing so can be arduous and lack modularity. Development of modular and more user amenable insertion methods is thus crucial to expand the biotechnological applications of oligonucleotides in what... Show more