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Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

By Jessica Scillieri Smith and others at
LogoDuke University
G-protein-coupled receptors (GPCRs) enable cells to sense and respond appropriately to hormonal and environmental signals, and are a target of ~30% of all FDA-approved medications. Canonically, each GPCR couples to distinct G proteins, such as Gs, Gi, Gq or G12/13, as well as {beta}-arrestins. These transducer proteins translate and integrate... Show more
January 21, 2021
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Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors
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