Sign in

Ni-Catalyzed Asymmetric Reductive Arylation of ⍺-Substituted Imides

By Li Ming Chen and others at
LogoCaltech
α-Aryl imides are common structural motifs in bioactive molecules and proteolysis-targeting chimeras designed for targeted protein deg-radation. An asymmetric Ni-catalyzed reductive cross-coupling of imide electrophiles and (hetero)aryl halides has been developed to synthesize enantioenriched α-arylglutarimides from simple starting materials. Judicious selection of electrophile pairs allows for coupling of both electron-rich... Show more
July 10, 2024
=
0
Loading PDF…
Loading full text...
Similar articles
Loading recommendations...
=
0
x1
Ni-Catalyzed Asymmetric Reductive Arylation of ⍺-Substituted Imides
Click on play to start listening