Multimodal repertoire analysis unveils B cell biology in health and immune-mediated diseases

ObjectivesDespite the involvement of B cells in the pathogenesis of immune-mediated diseases, biological mechanisms underlying their function are scarcely understood. To overcome this gap, here we constructed and investigated a large-scale repertoire catalog of five B cell subsets of immune-mediated disease patients. MethodsWe mapped B cell receptor regions from RNA sequencing... Show more