Merging Hydrogen-Atom-Transfer and the Truce-Smiles Rearrangement for Synthesis of beta-Arylethylamines from Unactivated Allylsulfonamides

Arylethylamines are crucial elements in pharmaceutical molecules, making methods for their synthesis highly significant. The Truce-Smiles rearrangement is a well-developed strategy to synthesize arylethylamine motifs via aryl migration. However, most examples require amide substrates to activate the alkene to attack by a radical precursor. This strategy both limits the product... Show more