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Impact of Acetylation, Succinylation, and pH on PEI-Based Polyplex Structure and Function

By Nazir Uddin and others at
LogoUniversity of Kentucky
Polyethylenimine (PEI), a widely used cationic polymer for nonviral gene delivery, often undergoes modification to enhance its transfection efficiency while reducing cytotoxicity. This study systematically examines the effects of acetylation and succinylation on PEI’s physicochemical properties, transfection efficiency, and DNA packaging within polymer-DNA complexes called polyplexes. We synthesized and characterized... Show more
May 9, 2024
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Impact of Acetylation, Succinylation, and pH on PEI-Based Polyplex Structure and Function
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