IFIH1 rs1990760 variants, systemic inflammation and outcome in critically-ill COVID-19 patients

RationaleOutcomes in patients with severe SARS-CoV-2 infection (COVID-19) are conditioned by virus clearance and regulation of inflammation. Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. ObjectiveTo characterize the impact of IFIH1 rs199076 variants on host response and outcomes after severe COVID-19. MethodsPatients admitted... Show more