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High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples

By Lujie Zhou and others
The current limitations of single-molecule localization microscopy (SMLM) in deep tissue imaging, primarily due to depth-dependent aberrations caused by refractive index (RI) mismatch, present a significant challenge in achieving high-resolution images at greater depths. To extend the imaging depth, we optimized the imaging buffer of SMLM with RI matched to... Show more
September 19, 2024
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High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples
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