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Discovery and Application of a Lysine 5-Hydroxylase for Bioorthogonal Chemistry

By Elizabeth Stone and others at
LogoUC Berkeley
The selective functionalization of unactivated C(sp3)–H bonds remains an ongoing challenge in synthetic organic chemistry. In this context, biocatalysis provides an attractive strategy to perform such chemistry under mild reaction conditions. We now report the discovery of K5H, the first enzyme that catalyzes the one-step conversion of free L-lysine into... Show more
July 3, 2024
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Discovery and Application of a Lysine 5-Hydroxylase for Bioorthogonal Chemistry
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