Sign in

DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance

By F. D'Anna and others
AO_SCPLOWBSTRACTC_SCPLOWO_ST_ABSBackgroundC_ST_ABSHypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcriptional response to hypoxia. ResultsHere, we report that HIFs fail to bind CpG dinucleotides that are methylated in... Show more
July 27, 2020
=
0
Loading PDF…
Loading full text...
Similar articles
Loading recommendations...
=
0
x1
DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance
Click on play to start listening