Coordinated Cortical Thickness Alterations across Psychiatric Conditions: A Transdiagnostic ENIGMA Study

IntroductionMental disorders are increasingly conceptualized as overlapping spectra with underlying polygenicity, neurodevelopmental etiology, and clinical comorbidity. They share multi-level neurobiological alterations, including network-like brain structural alterations. However, whether alteration patterns covary across mental disorders in a biologically meaningful way is currently unknown. MethodsWe accessed summary statistics on cortical thickness alterations from... Show more