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Chemogenetic activation of excitatory neurons alters hippocampal neurotransmission in a dose-dependent manner

By Sandhya Pati and others at
LogoTata Institute of Fundamental Research
Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are extensively used to manipulate neuronal activity in a cell-type specific manner. Whole-cell patch-clamp recordings indicate membrane depolarization, coupled with increased neuronal firing rate, following administration of the DREADD ligand, Clozapine-N-Oxide (CNO) to activate the Gq-coupled DREADD, hM3Dq. Although hM3Dq... Show more
October 23, 2019
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Chemogenetic activation of excitatory neurons alters hippocampal neurotransmission in a dose-dependent manner
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