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Chemoenzymatic Skeletal Editing: P450-Controlled Site-Selective Ring Expansion of Natural Product Scaffolds at Aliphatic C—H Sites

By Rudi Fasan and others at
LogoUniversity of Texas at Dallas
Methods for introducing subtle modifications at the level of single atoms/bonds (‘skeletal editing’) are highly desirable in organic and medicinal chemistry, owing to their potential for fine-tuning the structure and biological activity of organic molecules. While contemporary methods for skeletal editing of organic molecules largely rely on modification of pre-existing... Show more
July 5, 2024
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Chemoenzymatic Skeletal Editing: P450-Controlled Site-Selective Ring Expansion of Natural Product Scaffolds at Aliphatic C—H Sites
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