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Biophysical Methods for Attomolar Detection of Compounds Acting on Protein Oligomer States

By William Lawless and others at
LogoUniversity of South Florida
Few protocols exist today that demonstrate repeatable resolution of small molecule interactions with target proteins at extremely low analyte levels, particularly at sub-femtomolar levels. We have developed two approaches for rapid screening and biophysical analysis which leverage changes in protein oligomer states to study highly potent drug candidates. The first... Show more
July 2, 2024
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Biophysical Methods for Attomolar Detection of Compounds Acting on Protein Oligomer States
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