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Au(I)-catalysis Enables Regioselective Hydrogen Isotope Labeling of Indoles

By Pierre Milcendeau and others
The gold(I)-catalyzed hydrogen isotope exchange reaction on indoles and related heterocycles is described, under mild conditions and low catalyst loadings, using CD3OD and D2O as readily available deuterium sources. C3-unsubstituted indoles are labeled at the C3 position with an exquisite regioselectivity, while C3-substituted indoles are labeled at the C2 position.... Show more
June 11, 2024
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Au(I)-catalysis Enables Regioselective Hydrogen Isotope Labeling of Indoles
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