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Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria

By Ullas Kolthur-Seetharam and others at
LogoTata Institute of Fundamental Research
Anabolic and catabolic signalling mediated via mTOR and AMPK have to be intrinsically coupled to mitochondrial functions for maintaining homeostasis and mitigate cellular/organismal stress. Although, glutamine is known to activate mTOR, if/how differential mitochondrial utilization of glutamine impinges on mTOR signalling is less explored. Mitochondrial SIRT4, which unlike other sirtuins... Show more
November 1, 2019
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Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria
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