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Activity and cytosolic Na+ regulates synaptic vesicle endocytosis

By Yapeng Zhu and others at
LogoTulane University
Retrieval of synaptic vesicles via endocytosis is essential for maintaining sustained synaptic transmission, especially for neurons that fire action potentials at high frequencies. However, how activity regulates synaptic vesicles recycling is largely unknown. Here we report that Na+ substantially accumulated in the mouse calyx of Held terminals during repetitive high-frequency... Show more
June 30, 2020
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Activity and cytosolic Na+ regulates synaptic vesicle endocytosis
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