A continuous flow sulfuryl chloride based reaction – synthesis of a key intermediate in a new route toward emtricitabine and lamivudine

<p>We demonstrate a continuous two-step sequence where a sulfenyl chloride is formed, trapped by vinyl acetate and chlorinated further via a Pummerer rearrangement. This sequence produces a key intermediate in our new approach to the oxathiolane core used to prepare the anti-retroviral medicines Emtricitabine and Lamivudine. During batch scale-up to tens of grams, we found... Show more