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Chemical catalyst manipulating cancer epigenome and transcription

By Yuki Yamanashi and others
Post-translational modification (PTM) of histones dynamically regulates gene transcription and is closely related to cancer development. Altering the epigenome is thus a promising strategy for cancer chemotherapy. However, there have been no methods to artificially introduce physiologically relevant histone PTMs and their transcription profile without genetic engineering in living cells.... Show more
May 15, 2024
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