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The microbiome mediates subchondral bone loss and metabolomic changes after acute joint trauma

By A. Hahn and others at
LogoMontana State University
ObjectiveTo compare the early responses to joint injury in conventional and germ-free mice. DesignPost traumatic osteoarthritis PTOA was induced using a non-invasive anterior cruciate ligament rupture model in 20-week old germ-free (GF) and conventional C57BL/6 mice. Injury was induced in the left knees of n=8 GF and n=10 conventional mice. To... Show more
March 19, 2021
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