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Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame.

By Tharwat Mohy El-Dine and others
The solventless synthesis of peptides from unactivated amino acids was performed in a twin-screw extruder. The general method was applied to the preparation of dipeptides and tripeptides. Aspartame, a synthetic dipeptide, was also prepared in a continuous mode on large scale.
December 22, 2023
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Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame.
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