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From chemRxiv
Emory University

Photoredox-Driven Three-Component Coupling of Aryl Halides, Olefins, and O2

Modern organic synthesis requires methodologies that bring together abundant, feedstock chemicals in a mild and efficient manner. To aid in this effort, we have developed a multicomponent radical hydroxyarylation reaction that utilizes aryl hal-ides, olefins, and O2 as the reaction components. Crucial to this advance was an oxidative rather than reductive approach to aryl radical generation, which enables reaction tolerance to O2. This methodology displays a broad functional group tolerance with a variety of functionalized aryl halides and a broad array of olefins. Development of this methodology enables rapid access to biologically relevant hydroxyaryl products from simple, commercially available starting materials.
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Published on October 25, 2023
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