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Disruption of the CSF-1-CSF-1R axis alters cerebellar microglia and is associated with motor and social interaction defects

By V. Kana and others at
LogoIcahn School of Medicine at Mount Sinai
Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in the cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from forebrain microglia. Cerebellar microglial identity was driven by the CSF-1R ligand CSF-1, independently of the... Show more
July 26, 2019
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Disruption of the CSF-1-CSF-1R axis alters cerebellar microglia and is associated with motor and social interaction defects
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