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BAG3-dependent autophagy maintains sarcomere function in cardiomyocytes

By T. Martin and others
The association between reduced myofilament force-generating capacity (Fmax) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show the Fmax decrease arises from impaired BAG3-mediated sarcomere turnover. Myofilament BAG3 decreased in human HF and predicted the extent of Fmax decrease. This relationship was... Show more
May 19, 2021
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BAG3-dependent autophagy maintains sarcomere function in cardiomyocytes
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