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Unbiased organism-agnostic and highly sensitive signal peptide predictor with deep protein language model

14 December 2023 by Junbo Shen and others at

Broad Institute

Artificial Intelligence, Quantitative Methods

Reproducible image-based profiling with Pycytominer

2 July 2024 by Erik Serrano and others at

Broad Institute

Quantitative Methods

Generating Drug Repurposing Hypotheses through the Combination of Disease-Specific Hypergraphs

16 November 2023 by Ayush Jain and others at

Broad Institute

Biomolecules, Machine Learning

scX: A user-friendly tool for scRNA-seq exploration

7 March 2024 by Tomás Vega Waichman and others at

Broad Institute

Genomics

Graph AI in Medicine

20 October 2023 by Ruth Johnson and others at

Broad Institute

Machine Learning

Contextualized Machine Learning

17 October 2023 by Benjamin Lengerich and others at

Broad Institute

Machine Learning

Contextualized Policy Recovery: Modeling and Interpreting Medical Decisions with Adaptive Imitation Learning

7 May 2024 by Jannik Deuschel and others at

Broad Institute

Machine Learning, Artificial Intelligence

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

13 July 2023 by E. Weeks and others at

Broad Institute

Genetic and Genomic Medicine

Sensitive, high-throughput HLA-I and HLA-II immunopeptidomics using parallel accumulation-serial fragmentation mass spectrometry

3 May 2023 by K. Phulphagar and others at

Broad Institute

Immunology

A single-cell map of antisense oligonucleotide activity in the brain

16 May 2023 by M. Mortberg and others at

Broad Institute

Neuroscience

Therapeutic trial of anle138b in mouse models of genetic prion disease

18 January 2023 by S. Vallabh and others at

Broad Institute

Neuroscience

Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model

11 May 2023 by Surakshya Aryal and others at

Broad Institute

Neuroscience

Photoselective sequencing: microscopically-guided genomic measurements with subcellular resolution

27 April 2023 by S. Mangiameli and others at

Broad Institute

Genomics

Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies

28 August 2023 by P. Nowbandegani and others at

Broad Institute

Genetics

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

30 May 2023 by M. Berryer and others at

Broad Institute

Neuroscience

Temporal single cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury

20 February 2023 by I. Benhar and others at

Broad Institute

Immunology

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

6 September 2022 by P. Deweirdt and others at

Broad Institute

Bioengineering

Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials

21 October 2022 by M. Mortberg and others at

Broad Institute

Neurology

An automated high-content synaptic phenotyping platform in human neurons and astrocytes reveals a role for BET proteins in synapse assembly

21 April 2023 by M. Berryer and others at

Broad Institute

Neuroscience

Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection

12 December 2022 by M. Jankowiak and others at

Broad Institute

Genomics

Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

22 August 2022 by M. Mortberg and others at

Broad Institute

Neuroscience

Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

4 November 2022 by Masaki Kanai and others at

Broad Institute

Genetic and Genomic Medicine

Cell type-specific differential expression for spatial transcriptomics

1 September 2022 by D. Cable and others at

Broad Institute

Genomics

Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity

8 November 2022 by K. Tsuo and others at

Broad Institute

Allergy and Immunology

Genomic variation across a clinical Cryptococcus population linked to disease outcome

10 November 2022 by P. C. S. Sephton-Clark and others at

Broad Institute

Genomics

Biology-inspired data-driven quality control for scientific discovery in single-cell transcriptomics

27 December 2022 by Arravind Subramanian and others at

Broad Institute

Bioinformatics

Adjusting for Common Variant Polygenic Scores Improves Yield in Rare Variant Association Analyses

23 March 2023 by S. Jurgens and others at

Broad Institute

Genomics

Targeted in silico characterization of fusion transcripts in tumor and normal tissues via FusionInspector

8 May 2023 by Brittany Haas and others at

Broad Institute

Bioinformatics

Evaluation of the Access Bio CareStartTM rapid SARS-CoV-2 antigen test in asymptomatic individuals tested at a community mass-testing program in Western Massachusetts

9 December 2022 by Sammy Suliman and others at

Broad Institute

Infectious Diseases

CODEC enables 'single duplex' sequencing

27 April 2023 by Jae Hyeon Bae and others at

Broad Institute

Bioengineering

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Genomics Genetics Bioinformatics Neuroscience Genetic and Genomic Medicine Biochemistry Machine Learning Bioengineering Epidemiology Immunology Cancer Biology Molecular Biology Artificial Intelligence Quantitative Methods Neurology