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The Hospital for Sick Children
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38
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A shift in the mechanisms controlling hippocampal engram formation during brain maturation
4 May 2023 by
A. Ramsaran
and
others
at
The Hospital for Sick Children
Neuroscience
Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis
9 March 2023 by
Sebastian Grinstein
and
others
at
The Hospital for Sick Children
Cell Biology
Structure of V-ATPase from citrus fruit
29 August 2022 by
Yong Tan
and
others
at
The Hospital for Sick Children
Biochemistry
EHR Foundation Models Improve Robustness in the Presence of Temporal Distribution Shift
7 March 2023 by
Lin Lawrence Guo
and
others
at
The Hospital for Sick Children
Health Informatics
Structural basis of mammalian Complex IV inhibition by steroids
19 July 2022 by
J. Trani
and
others
at
The Hospital for Sick Children
Biophysics
Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada
24 August 2022 by
P. -P. Piche-Renaud
and
others
at
The Hospital for Sick Children
Infectious Diseases
Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles
7 June 2022 by
K. Khalaj
and
others
at
The Hospital for Sick Children
Developmental Biology
Genome-wide tandem repeat expansions contribute to schizophrenia risk
12 May 2022 by
B. Mojarad
and
others
at
The Hospital for Sick Children
Genetic and Genomic Medicine
Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis in Drosophila melanogaster
25 January 2023 by
Lianhe Shao
and
others
at
The Hospital for Sick Children
Developmental Biology
The impact of the COVID-19 pandemic on children with medical complexity
25 August 2022 by
C. Diskin
and
others
at
The Hospital for Sick Children
Pediatrics
Cryo-EM of the yeast VO complex reveals distinct binding sites for macrolide V-ATPase inhibitors
11 February 2022 by
K. Keon
and
others
at
The Hospital for Sick Children
Biochemistry
Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder
29 October 2022 by
A. J. S. Chan
and
others
at
The Hospital for Sick Children
Genetic and Genomic Medicine
Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats
13 January 2022 by
I. Kucharska
and
others
at
The Hospital for Sick Children
Molecular Biology
Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut
18 November 2021 by
Alexej Popovič
and
others
at
The Hospital for Sick Children
Microbiology
Evaluation of Domain Generalization and Adaptation on Improving Model Robustness to Temporal Dataset Shift in Clinical Medicine
17 February 2022 by
Lin Lawrence Guo
and
others
at
The Hospital for Sick Children
Health Systems and Quality Improvement
Mouse models of immune dysfunction: Their neuroanatomical differences reflect their anxiety-behavioural phenotype
14 April 2022 by
D. Fernandes
and
others
at
The Hospital for Sick Children
Neuroscience
Saturation variant interpretation using CRISPR prime editing
21 February 2022 by
S. Erwood
and
others
at
The Hospital for Sick Children
Genetics
Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38
21 May 2021 by
Chenzhi Tan
and
others
at
The Hospital for Sick Children
Cell Biology
Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL/SLAP2 crystal complex
2 February 2021 by
L. Wybenga-Groot
and
C. Mcglade
at
The Hospital for Sick Children
Biochemistry
Wide phenotypic spectrum of human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
18 October 2022 by
Rebecca Mok
and
others
at
The Hospital for Sick Children
Neuroscience
Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide
20 August 2020 by
S. Isabel
and
others
at
The Hospital for Sick Children
Bioinformatics
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11
30 November 2020 by
I. Kucharska
and
others
at
The Hospital for Sick Children
Microbiology
PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation
29 June 2020 by
L. Marmont
and
others
at
The Hospital for Sick Children
Microbiology
Electron Event Representation (EER) data enables efficient cryoEM file storage with full preservation of spatial and temporal resolution
6 August 2020 by
Hongda Guo
and
others
at
The Hospital for Sick Children
Biophysics
Modelling Niemann-Pick disease type C in a human haploid cell line allows for patient variant characterization and clinical interpretation.
21 November 2019 by
S. Erwood
and
others
at
The Hospital for Sick Children
Genetics
Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster
1 April 2020 by
G. Whitfield
and
others
at
The Hospital for Sick Children
Microbiology
BOLD differences normally attributed to inhibitory control predict symptoms, not task-directed inhibitory control in ADHD
21 February 2020 by
A. Chevrier
and
R. Schachar
at
The Hospital for Sick Children
Neuroscience
Multiple conformations facilitate PilT function in the type IV pilus
15 November 2019 by
Mason Mccallum
and
others
at
The Hospital for Sick Children
Microbiology
Control iPSC lines with clinically annotated genetic variants for versatile multi-lineage differentiation
10 December 2020 by
M. Hildebrandt
and
others
at
The Hospital for Sick Children
Developmental Biology
Shake-it-off: A simple ultrasonic cryo-EM specimen preparation device
21 November 2019 by
J. Rubinstein
and
others
at
The Hospital for Sick Children
Biophysics
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Topics
Neuroscience
Microbiology
Cell Biology
Biochemistry
Developmental Biology
Biophysics
Genetic and Genomic Medicine
Genetics
Health Informatics
Pediatrics
Infectious Diseases
Health Systems and Quality Improvement
Molecular Biology
Bioinformatics
Systems Biology